![]() It appears in one of 1000 newborns, with 50–70% of cases attributable to genetic causes (Morton and Nance, 2006). Conclusion: The Ion Personal Genome Machine system had sufficient uniformity and accuracy for application to the clinical diagnosis of common causative mutations and efficiently identified rare causative mutations and/or mutation candidates.Ĭ ongenital hearing loss is one of the most common sensory disorders. Results: We compared the results of Invader assay-based genetic screening, the accuracy of which has already been verified in previous studies, with those of MPS-based genetic testing for a large population of Japanese deafness patients and revealed that over 99.98% of the results were the same for each genetic testing system. Before its clinical application, we investigated the accuracy of MPS-based genetic testing. Aim: Toward more effective genetic testing, we adopted Massively Parallel DNA Sequencing (MPS) of target genes using an Ion PGM™ system and an Ion AmpliSeq™ panel to diagnose common mutations responsible for deafness and discover rare causative gene mutations. Although recent advances in the identification of deafness genes have resulted in more accurate molecular diagnosis, leading to the better determination of suitable clinical interventions, difficulties remain with regard to clinical applications due to the extreme genetic heterogeneity of deafness. Bardem most recently acted in the crime drama "Escobar: Paradise Lost" (2015) with Benicio Del Toro.Background: Congenital hearing loss is one of the most common sensory disorders, with 50–70% of cases attributable to genetic causes. He also appeared in "Elvira, te daría mi vida pero la estoy usando" (2015) with Cecilia Suárez. In his more recent career, he continued to act in "Transgression" (2013), "Violet" (2013) with Junio Valverde and the Tenoch Huerta Mejia thriller "Days of Grace" (2014). He continued to act in productions like the Benicio Del Toro dramatic adaptation "Che: Part Two" (2008), "El Nino pez" (2009) and "Entre Lobos" (2010). He also appeared in the crime drama "La Senal" (2007) with Diego Peretti and the Maribel Verdú crime drama "La Zona" (2007). Bardem started his acting career landing roles in such films as "Perdita Durango" (2000) with Rosie Perez, the Ana Torrent drama "El Juego de Luna" (2003) and "Cien maneras de acabar con el amor" (2005). Carlos Bardem rose to fame as an actor, gracing the silver screen many times over the course of his Hollywood career. ![]()
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